MRI verified STN stimulation site – gait improvement and clinical outcome
Identifieur interne : 000650 ( Main/Exploration ); précédent : 000649; suivant : 000651MRI verified STN stimulation site – gait improvement and clinical outcome
Auteurs : E. L. Johnsen ; N. Sunde ; P. H. Mogensen [Danemark] ; K. StergaardSource :
- European Journal of Neurology [ 1351-5101 ] ; 2010-05.
English descriptors
Abstract
Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is effective in alleviating Parkinson’s disease (PD) symptoms (tremor, rigidity and bradykinesia) and may improve gait and postural impairment associated with the disease. However, improvement of gait is not always as predictable as the clinical outcome. This may relate to the type of gait impairment or localization of the active DBS contact. Methods: The active contact was visualized on peri‐operative magnetic resonance imaging in 22 patients with idiopathic PD, consecutively treated with bilateral STN DBS. Stimulation site was grouped as either in the dorsal/ventral STN or medial/lateral hereof and anterior/posterior STN or medial/lateral hereof. The localization was compared with relative improvement of clinical outcome (UPDRS‐III). In 10 patients, quantitative gait analyses were performed, and the improvement in gait performance was compared with stimulation site in the STN. Results: Of 44 active contacts, 77% were inside the nucleus, 23% were medial hereof. Stimulation of the dorsal half improved UPDRS‐III significantly more than ventral STN DBS (P = 0.02). However, there were no differences between anterior and posterior stimulation in the dorsal STN. Step velocity and length improved significantly more with dorsal stimulation compared with ventral stimulation (P = 0.03 and P = 0.02). Balance during gait was also more improved with dorsal stimulation compared with ventral stimulation. Conclusions: Deep brain stimulation of the dorsal STN is superior to stimulation of the ventral STN. Possible different effects of stimulation inside the nucleus underline the need for exact knowledge of the active stimulation site position to target the most effective area.
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DOI: 10.1111/j.1468-1331.2010.02962.x
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Stergaard</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D5C382F7765706D50D642E9490C069D8D388DFC1</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1111/j.1468-1331.2010.02962.x</idno><idno type="url">https://api.istex.fr/document/D5C382F7765706D50D642E9490C069D8D388DFC1/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000643</idno><idno type="wicri:Area/Main/Curation">000560</idno><idno type="wicri:Area/Main/Exploration">000650</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">MRI verified STN stimulation site – gait improvement and clinical outcome</title><author><name sortKey="Johnsen, E L" sort="Johnsen, E L" uniqKey="Johnsen E" first="E. L." last="Johnsen">E. L. Johnsen</name><affiliation><wicri:noCountry code="no comma">Departments of Neurology</wicri:noCountry></affiliation></author><author><name sortKey="Sunde, N" sort="Sunde, N" uniqKey="Sunde N" first="N." last="Sunde">N. Sunde</name><affiliation><wicri:noCountry code="subField">Aarhus</wicri:noCountry></affiliation></author><author><name sortKey="Mogensen, P H" sort="Mogensen, P H" uniqKey="Mogensen P" first="P. H." last="Mogensen">P. H. Mogensen</name><affiliation wicri:level="1"><country xml:lang="fr">Danemark</country><wicri:regionArea>Gait Laboratory, Hammel Neurocenter, Hammel</wicri:regionArea><wicri:noRegion>Hammel</wicri:noRegion></affiliation></author><author><name sortKey=" Stergaard, K" sort=" Stergaard, K" uniqKey=" Stergaard K" first="K." last=" Stergaard">K. Stergaard</name><affiliation><wicri:noCountry code="no comma">Departments of Neurology</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-05">2010-05</date><biblScope unit="volume">17</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="746">746</biblScope><biblScope unit="page" to="753">753</biblScope></imprint><idno type="ISSN">1351-5101</idno></series><idno type="istex">D5C382F7765706D50D642E9490C069D8D388DFC1</idno><idno type="DOI">10.1111/j.1468-1331.2010.02962.x</idno><idno type="ArticleID">ENE2962</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-5101</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>MRI</term><term>Parkinson’s disease</term><term>deep brain stimulation</term><term>gait analysis</term><term>subthalamic nucleus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is effective in alleviating Parkinson’s disease (PD) symptoms (tremor, rigidity and bradykinesia) and may improve gait and postural impairment associated with the disease. However, improvement of gait is not always as predictable as the clinical outcome. This may relate to the type of gait impairment or localization of the active DBS contact. Methods: The active contact was visualized on peri‐operative magnetic resonance imaging in 22 patients with idiopathic PD, consecutively treated with bilateral STN DBS. Stimulation site was grouped as either in the dorsal/ventral STN or medial/lateral hereof and anterior/posterior STN or medial/lateral hereof. The localization was compared with relative improvement of clinical outcome (UPDRS‐III). In 10 patients, quantitative gait analyses were performed, and the improvement in gait performance was compared with stimulation site in the STN. Results: Of 44 active contacts, 77% were inside the nucleus, 23% were medial hereof. Stimulation of the dorsal half improved UPDRS‐III significantly more than ventral STN DBS (P = 0.02). However, there were no differences between anterior and posterior stimulation in the dorsal STN. Step velocity and length improved significantly more with dorsal stimulation compared with ventral stimulation (P = 0.03 and P = 0.02). Balance during gait was also more improved with dorsal stimulation compared with ventral stimulation. Conclusions: Deep brain stimulation of the dorsal STN is superior to stimulation of the ventral STN. Possible different effects of stimulation inside the nucleus underline the need for exact knowledge of the active stimulation site position to target the most effective area.</div></front></TEI><affiliations><list><country><li>Danemark</li></country></list><tree><noCountry><name sortKey=" Stergaard, K" sort=" Stergaard, K" uniqKey=" Stergaard K" first="K." last=" Stergaard">K. Stergaard</name><name sortKey="Johnsen, E L" sort="Johnsen, E L" uniqKey="Johnsen E" first="E. L." last="Johnsen">E. L. 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